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ROLUL IMPORTANT AL PIPERINEI IN BOLILE CRONICE SI CANCER

Omenirea si bolile secolului XXI

Datorita schimbarilor in alimentatie si stilului de viata, oamenii sunt mai predispusi la diverse boli si tulburari, cancerul aflandu-se printre cele mai frecvente dintre ele. Cancerul gastric are a doua rata de malignitate fatala in lume [1].

Cercetarile asupra cancerului gastric indus de microorganisme nu au fost intense, de aceea acum cercetatorii se concentreaza in detaliu pe oncogeneza indusa microbiologic. Optzeci la suta din cazurile de cancer gastric diagnosticate sunt considerate a fi induse de microbi. [2]. Dupa descoperirea Helicobacter pylori de catre Marshall si Warren la un pacient cu gastrita, s-au realizat numeroase studii de microbiologie asupra influentei acestei bacterii in diversele patologii ale sistemul digestiv. [3]. Numeroase rapoarte sugereaza ca debutul infectiei cu H. pylori in copilarie apare prin relatii de sange vizand tatal, mama si fratii. [4] Este ingrijorator faptul ca aproximativ jumatate din populatia mondiala este infectata cu acest agent patogen [5]. H. pylori joaca un rol determinant la pacientii cu gastrita cronica, ulcere peptice, adenocarcinoame gastrice si formatiuni limfoide ale mucoasei gastrice [6,7]. H. pylori este cunoscut pentru producerea mai multor factori virali (de exemplu, CagA, VacA, peptidoglican si alti multi factori de aderenta care sunt considerati cei mai importanti factori de virulenta) [8]. OMS a declarat H. pylori carcinogen, deoarece este asociat cu adenocarcinomul gastric [9]. Dupa o infectie importanta , o varietate de factori de virulenta se traduc in celule epiteliale gastrice [8]. Proteina citotoxica CagA este transpusa in celulele epiteliale gastrice prin intermediul sistemului de secretie de tip IV [10], aceasta fiind considerata cauza principala a producerii cancerului gastric.

Numerosi agenti chimioterapeutici sunt disponibili pentru tratamentul cancerului, desi ei au efecte citotoxice si asupra celulelor normale [29].

Totodata insa , mai multe studii raporteaza ca unii compusi naturali si unele suplimentele nutritive manifesta o bioactivitate importanta impotriva cancerului [30].

Aportul de alimente naturale, cum ar fi legumele si fructele, determina o scadere a incidentei cancerului [20]. Cercetatorii se concentreaza acum pe acesti compusi naturali si realizeaza numeroase investigatii clinice privind efectele lor. Rapoartele sugereaza ca aportul de legume in cantitate mai mare de 400 g / zi poate reduce dezvoltarea cancerului cu pana la 20% [20]. Suplimentele alimentare care contin compusi bioactivi sunt acum considerati deosebit de importanti si sunt studiati pe larg pentru actiunea lor anticancerigena.

In urma unui studiu sustinut la Universitatea Yonsei din Coreea de Sud, s-au raportat numeroase efecte benefice ale Piperinei in prevenirea si tratamentul bolilor cronice, in special acele efecte care vizeaza reducerea riscurilor de cancer si actiunea sa importanta impotriva infectiei cu H. pylori.

Ce este Piperina?

Piperul negru (Piper nigrum) este cunoscut drept „regele mirodeniilor”. Piperina este un alcaloid prezent in Piperul negru (Piper nigrum) sau Ardeiul negru, cum se mai numeste acesta in literatura anglo-saxona, unul dintre cele mai utilizate condimente. Mai gasim, de asemenea, Piperina si in Ardeiul lung (Piper longum) si in alte fructe ale unor plante apartinand familiei Piperaceae. Alcaloizii includ o familie de compusi chimici naturali care contin in principal azot. Piperina, o substanta azotata care este deosebit de prezenta in Piperul negru, se crede ca isi exercita functia mai ales la nivel gastrointestinal [22], fiind un compus natural folosit ca potentator alimentar si raportat ca un compus cu efecte anticancerigene [31,32]. Dupa numeroase studii medicale s-a constatat ca rezistenta la medicamente a H. pylori a crescut continuu in timp [33]. Pe baza acestei constatari, cercetatorii au cautat compusul natural care ar putea actiona impotriva H. pylori, Piperina fiind gasita ca prim agent de protectie impotriva ulcerelor gastrice [34], avand un rol antibacterian, antiinflamator, dovedindu-se astfel a fi si un anticancerigen important.

Efectele farmacologice si beneficiile Piperinei asupra sanatatii:

  1. Protejeaza organismul in cazul racelilor obisnuite, tusei, bolilor din sfera ORL si febrei intermitente;
  2. Benefic in caz de colici si dizenterie;
  3. Eficient in lupta impotriva bolilor cronice;
  4. Reduce rezistenta la insulina;
  5. Reduce simptomele steatozei hepatice;
  6. Previne si combate diverse inflamatiile [21];
  7. Actioneaza impotriva cancerului prin inhibarea celulara in metastazele pulmonare [23] si, in cancerul de prostata, prin inhibarea proliferarii celulelor cauzatoare ale bolii.[24];
  8. Inhiba cresterea bacteriilor si previne aderenta acestora la celulele epiteliale gastrice. Are un efect sinergic asupra functiei antibacteriene atunci cand se combina cu ciprofloxacina (antibiotic din familia chinolonelor) ;
  9. Avand in vedere ca Piperina restrictioneaza cresterea si aderenta bacteriana, aceasta are un rol foarte important si in tratarea infectiei cu H. pylori. Piperina actioneaza ca un inhibitor al pompei de reflux bacterian inhiband cresterea bacteriana chiar si in tulpinile multifunctionale rezistente [52-54];
  10. S-a raportat ca Piperina poate actiona cu succes impotriva declansarii cancerului [23,29,31]. Efectele supresive ale Piperinei asupra nivelului de β-catenina din celulele infectate cu H. pylori au sustinut ideea ca Piperina este unul dintre agentii activi care au suprimat declansarea cancerului gastric.

Concluziile cercetatorilor in privinta cancerului gastric tratat cu Piperina:

Primul aspect in cazul utilizarii Piperinei in infectia cu H. pylori si impotriva proliferarii celulelor adenocarcinomului gastric a fost acela ca administrarea acesteia in timpul infectiei cu H. pylori a scazut clivajul de E-cadherina si nivelul de β-catenina, a scazut secretia de interleucina [46-48] si de IL-8 in celulele infectate cu H. pylori.

Tratamentul cu Piperina suprima intrarea Helicobacter pylori in epiteliul gastric si reduce la minimum oncogeneza mediata de β-catenina si secretia de IL-8 in vitro.

Efectul major al Piperinei consta in capacitatea ei considerabila de inhibare a inflamatiei.

Recomandari

Consumul zilnic de Ardei negru reduce sansele de infectie si cancer gastric cauzate de H. pylori.

Aproximativ 600 mg de Piper negru, luate zilnic, pot preveni infectia cu H. pylori și efectul sau carcinogen la nivel gastric.

Va  recomandam suplimentul nostru BIOPIPERINE, pentru o eficienta maxima.

BIOPIPERINE (BIOPIPERINA)

  • Foarte bun potentator de absorbtie fitonutritieni.
  • Initiator termogeneza (arderea grasimilor inutile).
  • Mareste considerabil gradul de bioabsorbtie al suplimentelor nutritive, a vitaminelor si alimentelor.
  • Imbunatateste metabolismul.

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